The role of tunneling nanotubes during early stages of HIV infection and reactivation: implications in HIV cure.
Silvana ValdebenitoAkira OnoLibin RongEliseo A EugeninPublished in: NeuroImmune pharmacology and therapeutics (2023)
Tunneling nanotubes (TNTs), also called cytonemes or tumor microtubes, correspond to cellular processes that enable long-range communication. TNTs are plasma membrane extensions that form tubular processes that connect the cytoplasm of two or more cells. TNTs are mostly expressed during the early stages of development and poorly expressed in adulthood. However, in disease conditions such as stroke, cancer, and viral infections such as HIV, TNTs proliferate, but their role is poorly understood. TNTs function has been associated with signaling coordination, organelle sharing, and the transfer of infectious agents such as HIV. Here, we describe the critical role and function of TNTs during HIV infection and reactivation, as well as the use of TNTs for cure strategies.
Keyphrases
- antiretroviral therapy
- hiv infected
- hiv positive
- human immunodeficiency virus
- hiv testing
- hiv aids
- hepatitis c virus
- men who have sex with men
- induced apoptosis
- sars cov
- social media
- squamous cell carcinoma
- signaling pathway
- atrial fibrillation
- healthcare
- cell death
- blood brain barrier
- subarachnoid hemorrhage
- high glucose