Pharmacokinetic-Pharmacodynamic Modelling in Hemophilia A: Relating Thrombin and Plasmin Generation to Factor VIII Activity After Administration of a VWF/FVIII Concentrate.
Lars L F G ValkeMichael E CloesmeijerHassan MansouritorghabehWideke BartelingNicole M A BlijlevensMarjon H CnossenRon A A MathôtSaskia E M ScholsWaander L van HeerdePublished in: European journal of drug metabolism and pharmacokinetics (2024)
Our predictive performance displayed adequate thrombin pharmacodynamic predictions of the original model, but a new pharmacokinetic model was required. The pharmacodynamic model is not factor specific and applicable to multiple factor concentrates. A prospective study is needed to validate the impact of the FVIII dosing pharmacodynamic model on bleeding reduction in patients.