Inhibition of SIRT1 Limits Self-Renewal and Oncogenesis by Inducing Senescence of Liver Cancer Stem Cells.
Min-Jun WangJia-Jia ChenShao-Hua SongJing SuLing-Hao ZhaoQing-Gui LiuTao YangZhiwen ChenChang LiuZhi-Ren FuYi-Ping HuFei ChenPublished in: Journal of hepatocellular carcinoma (2021)
Taken together, these findings pointed that induction of senescence in liver CSCs is an effective tumor suppression method for HCC, and SIRT1 may be served as a promising target for HCC treatment.