TIGIT blockade repolarizes AML-associated TIGIT + M2 macrophages to an M1 phenotype and increases CD47-mediated phagocytosis.
Franziska BrauneckBrit FischerMarius WittJana MuschhammerJennyfer OelrichPedro Henrique da Costa AvelarSophia TsokaLars BullingerElisa SeubertDaniel J SmitCarsten BokemeyerChristin AckermannJasmin WellbrockFriedrich HaagWalter FiedlerPublished in: Journal for immunotherapy of cancer (2022)
M2 LAMs can be redirected into an efficient effector population that may be of direct clinical relevance in the near future.