Distinctive retinal peri-arteriolar versus peri-venular amyloid plaque distribution correlates with the cognitive performance.
Oana M DumitrascuJonah DoustarDieu-Trang FuchsYosef KoronyoDale S ShermanMichelle Shizu MillerKenneth O JohnsonRoxana O CarareSteven R VerdoonerPatrick D LydenJulie A SchneiderKeith L BlackMaya Koronyo-HamaouiPublished in: bioRxiv : the preprint server for biology (2024)
Retinal peri-arteriolar region exhibits more amyloid compared with peri-venular regions.Secondary retinal vascular branches have significantly higher perivascular amyloid burden in subjects with impaired cognition, consistent across sexes.Cognitively impaired individuals have significantly greater retinal peri-venular amyloid deposits in the distal small branches, that correlate with CDR and hippocampal volumes.