Long-term sorbitol consumption affects the hippocampus and alters cognitive function in aged mice.
Haruna YokoiJingshu WangYoriko IkuyoMitsuyoshi YamadaYosuke ShikamaMasae FurukawaKenji MatsushitaPublished in: Genes to cells : devoted to molecular & cellular mechanisms (2024)
The systemic effects of the artificial sweetener sorbitol on older adult individuals have not been elucidated. We assessed the effects of sorbitol consumption on cognitive and gingival health in a mouse model. Aged mice were fed 5% sorbitol for 3 months before their behavior was assessed, and brain and gingival tissues were collected. Long-term sorbitol consumption inhibited gingival tissue aging in aged mice. However, it caused cognitive decline and decreased brain-derived neurotrophic factor (BDNF) in the hippocampus. Sorbitol consumption did not affect homeostatic function; however, it may exert effects within the brain, particularly in the hippocampus.
Keyphrases
- cognitive decline
- cerebral ischemia
- high fat diet induced
- mouse model
- mild cognitive impairment
- healthcare
- white matter
- prefrontal cortex
- public health
- cognitive impairment
- mental health
- resting state
- physical activity
- gene expression
- type diabetes
- multiple sclerosis
- climate change
- metabolic syndrome
- blood brain barrier
- brain injury
- middle aged
- skeletal muscle
- childhood cancer