Non-invasive diagnosis of cirrhosis and long-term disease monitoring by transient elastography in patients with Wilson disease.
Rafael PaternostroJan PfeiffenbergerPeter FerenciAlbert Friedrich StättermayerRudolf E StauberFritz WrbaThomas LongerichKaroline LacknerMichael TraunerArnulf FerlitschThomas ReibergerKarl Heinz WeissPublished in: Liver international : official journal of the International Association for the Study of the Liver (2020)
TE-based LSM ≥9.9 kPa accurately identifies cirrhosis in WD patients. Next to TE-LSM <9.9 kPa, APRI <1.5 and FIB-4 <3.25 values assist to non-invasively rule out cirrhosis. LSM remains stable in most non-cirrhotic patients on WD therapy, while one-third of cirrhotic patients present clinically relevant decreases in LSM.