Clonal relationship and alcohol consumption-associated mutational signature in synchronous hypopharyngeal tumours and oesophageal squamous cell carcinoma.

Josephine Mun-Yee KoChen GuoConghui LiuLvwen NingWei Dai Lihua Tao Anthony Wing-Ip Lo Carissa Wing-Yan WongIan Yu-Hong WongFion Siu-Yin ChanClaudia Lai-Yin WongKwan Kit ChanTsz Ting LawNikki Pui-Yue Lee Zhi-Chao LiuHaoyao JiangZhigang LiSimon LawMaria Li Lung

Published in: British journal of cancer (2022)

Our hypothesis-generating M-WES ITH assessment data have implications for prognostication. Collectively, our findings support multicentric independent clonal evolution, the field cancerisation theory, and suggest novel insights implicating an aetiologic role of alcohol metabolism in dual ESCC/HPC carcinogenesis.

Keyphrases

alcohol consumption
squamous cell carcinoma
electronic health record
big data
locally advanced
radiation therapy
data analysis
machine learning
artificial intelligence