Abnormal Lymphatic Sphingosine-1-Phosphate Signaling Aggravates Lymphatic Dysfunction and Tissue Inflammation.
Dongeon KimWen TianTimothy Ting-Hsuan WuMenglan XiangRyan VinhJason Lon ChangShenbiao GuSeunghee LeeYu ZhuTorrey GuanEmilie Claire SchneiderEvan BaoJ Brandon DixonPeter N KaoJunliang PanStanley G RocksonXinguo JiangMark Robert NicollsPublished in: Circulation (2023)
This study suggests that reduction of the LEC S1P signaling aggravates lymphedema by enhancing LEC adhesion and amplifying pathogenic CD4 T-cell responses. P-selectin inhibitors are suggested as a possible treatment for this pervasive condition.