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The gut-immune-liver axis in patients with alcohol use disorder and clinically low serum zinc levels.

Aishwarya ThakurdesaiSuman K JhaIyabo ErinkitolaAula SaidThwisha JoshiMelanie L SchwandtDipendra ParajuliAshwani K SingalMaiying KongMatthew C CaveVatsalya Vatsalya
Published in: Alcohol, clinical & experimental research (2024)
Our findings demonstrated the role of the gut-immune-liver axis in describing hepatocyte injury and death in zinc-deficient AUD patients. These patients represented an arrangement of gut-barrier dysfunction and an exacerbated immune response. Shift in the cell-death mechanism from apoptosis in zinc-replete females to necrosis in zinc-deficient females suggests a subclinical to clinical transition of ALD associated with zinc status.
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