Chronic mechanical trauma/irritation and oral carcinoma: A systematic review showing low evidence to support an association.

Monica Pentenero Lorenzo Azzi Giovanni Lodi Maddalena Manfredi Elena Maria Varoni

Published in: Oral diseases (2021)

Available evidence does not support an active role for chronic trauma in oral carcinogenesis, neither as promoter nor as progressor factor. Prospective cohort studies able to better assess trauma in OSCC are needed.

Keyphrases

trauma patients
dna methylation
gene expression
drug induced