Associations between DNA methylation and BMI vary by metabolic health status: a potential link to disparate cardiovascular outcomes.
Whitney L DoSteve NguyenJie YaoXiuqing GuoEric A WhitselEllen DemerathJerome I RotterStephen S RichLeslie LangeJingzhong DingDavid Van Den BergYongmei LiuAnne E JusticeWeihua GuanSteve HorvathThemistocles L AssimesParveen BhattiKristina JordahlAladdin ShadyabCelina I ValenciaAryeh D SteinAlicia SmithLisa R StaimezKaren ConneelyK M Venkat NarayanPublished in: Clinical epigenetics (2021)
Differential associations between DNAm and BMI by MHZ were identified at 22 sites, one of which was validated (cg18989722) and three of which were predictive of incident CHD. These sites are located in several genes related to NF-kappa-B signaling, suggesting a potential role for inflammation between DNA methylation and BMI-associated metabolic health.