The addition of chemotherapy to adjuvant radiation is associated with inferior survival outcomes in intermediate-risk HPV-negative HNSCC.

Jason TasoulasNicholas R LenzeDouglas FarquharTravis P SchrankColette ShenM Ali ShazibBart SingerShetal PatelJuneko E Grilley OlsonDavid N HayesMargaret L GulleyBhishamjit S CheraTrevor HackmanAndrew F OlshanJared WeissSiddharth H Sheth

Published in: Cancer medicine (2021)

In high-risk patients, adjuvant chemoradiotherapy improved OS compared to RT alone. The greatest benefit was in node-positive cases. In intermediate-risk patients, the addition of chemotherapy to RT increased mortality risk and therefore should only be used cautiously in these patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
early stage
prognostic factors
peritoneal dialysis
locally advanced
lymph node
patient reported