The effect of energy restriction on development and progression of chronic kidney disease: review of the current evidence.
Baris AfsarRengin Elsurer AfsarSidar CopurAlan A SagAlberto OrtizMehmet KanbayPublished in: The British journal of nutrition (2020)
Energy restriction (ER) has anti-ageing effects and probably protects from a range of chronic diseases including cancer, diabetes and chronic kidney disease (CKD). Specifically, ER has a positive impact on experimental kidney ageing, CKD (diabetic nephropathy, polycystic kidney disease) and acute kidney injury (nephrotoxic, ischaemia-reperfusion injury) through such mechanisms as increased autophagy, mitochondrial biogenesis and DNA repair, and decreased inflammation and oxidative stress. Key molecules contributing to ER-mediated kidney protection include adenosine monophosphate-activated protein kinase, sirtuin-1 and PPAR-γ coactivator 1α. However, CKD is a complex condition, and ER may potentially worsen CKD complications such as protein-energy wasting, bone-mineral disorders and impaired wound healing. ER mimetics are drugs, such as metformin and Na-glucose co-transporter-2 which mimic the action of ER. This review aims to provide comprehensive data regarding the effect of ER on CKD progression and outcomes.
Keyphrases
- chronic kidney disease
- end stage renal disease
- oxidative stress
- endoplasmic reticulum
- estrogen receptor
- breast cancer cells
- dna repair
- acute kidney injury
- diabetic nephropathy
- dna damage
- type diabetes
- protein kinase
- cardiovascular disease
- metabolic syndrome
- risk factors
- young adults
- signaling pathway
- glycemic control
- acute myocardial infarction
- big data
- body composition
- blood pressure
- papillary thyroid
- percutaneous coronary intervention
- small molecule
- machine learning
- blood glucose
- lymph node metastasis
- drug induced
- deep learning
- childhood cancer