A Type 1 Diabetes Polygenic Score Is Not Associated With Prevalent Type 2 Diabetes in Large Population Studies.
Shylaja SrinivasanPeitao WuJosep Maria MercaderMiriam S UdlerBianca C PornealaTraci M BartzJames S FloydColleen M SitlaniXiquing GuoJeffrey HaesslerCharles KooperbergJun LiuShahzad AhmadCornelia M Van DuijnChing-Ti LiuMark O GoodarziJose C FlorezJames B MeigsJerome I RotterStephen S RichJosée DupuisAaron LeongPublished in: Journal of the Endocrine Society (2023)
In large biobank samples, a common variant PS for T1D was not consistently associated with prevalent T2D. However, possible heterogeneity in T2D cannot be ruled out and future studies are needed do subphenotyping.