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A Type 1 Diabetes Polygenic Score Is Not Associated With Prevalent Type 2 Diabetes in Large Population Studies.

Shylaja SrinivasanPeitao WuJosep Maria MercaderMiriam S UdlerBianca C PornealaTraci M BartzJames S FloydColleen M SitlaniXiquing GuoJeffrey HaesslerCharles KooperbergJun LiuShahzad AhmadCornelia M Van DuijnChing-Ti LiuMark O GoodarziJose C FlorezJames B MeigsJerome I RotterStephen S RichJosée DupuisAaron Leong
Published in: Journal of the Endocrine Society (2023)
In large biobank samples, a common variant PS for T1D was not consistently associated with prevalent T2D. However, possible heterogeneity in T2D cannot be ruled out and future studies are needed do subphenotyping.
Keyphrases
  • type diabetes
  • glycemic control
  • case control
  • cardiovascular disease
  • insulin resistance
  • single cell
  • current status
  • metabolic syndrome
  • adipose tissue
  • skeletal muscle
  • weight loss