COVID-19 Pandemic: Cardiovascular Complications and Future Implications.
Dhrubajyoti BandyopadhyayTauseef AkhtarAdrija HajraManasvi GuptaAvash DasSandipan ChakrabortyIpsita PalNeelkumar PatelBirendra AmgaiRaktim K GhoshGregg C FonarowCarl J LavieSrihari S NaiduPublished in: American journal of cardiovascular drugs : drugs, devices, and other interventions (2020)
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is now a global pandemic with the highest number of affected individuals in the modern era. Not only is the infection inflicting significant morbidity and mortality, but there has also been a significant strain to the health care system and the economy. COVID-19 typically presents as viral pneumonia, occasionally leading to acute respiratory distress syndrome (ARDS) and death. However, emerging evidence suggests that it has a significant impact on the cardiovascular (CV) system by direct myocardial damage, severe systemic inflammatory response, hypoxia, right heart strain secondary to ARDS and lung injury, and plaque rupture secondary to inflammation. Primary cardiac manifestations include acute myocarditis, myocardial infarction, arrhythmia, and abnormal clotting. Several consensus documents have been released to help manage CV disease during this pandemic. In this review, we summarize key cardiac manifestations, their management, and future implications.
Keyphrases
- acute respiratory distress syndrome
- respiratory syndrome coronavirus
- sars cov
- coronavirus disease
- extracorporeal membrane oxygenation
- left ventricular
- respiratory failure
- mechanical ventilation
- inflammatory response
- heart failure
- oxidative stress
- current status
- drug induced
- liver failure
- endothelial cells
- risk factors
- coronary artery disease
- immune response
- aortic dissection