Rim-differentiated Co-pillar[4+1]arenes.

A series of rim-differentiated Co-pillar[4+1]arenes featuring penta-substituted "upper" rims and mono-functionalisable "lower" rims was successfully synthesised and fully characterised. These novel pillar[5]arene-based scaffolds with clickable moieties and extra synthetic handles are versatile platforms for self-assembled molecular architectures and biological applications.