A Retrospective Review on Dysregulated Autophagy in Polycystic Ovary Syndrome: From Pathogenesis to Therapeutic Strategies.
Yan ZhaoXiaoxuan ZhaoTianyue JiangHongyan XiYuepeng JiangXiaoling FengPublished in: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme (2024)
The main purpose of this article is to explore the relationship between autophagy and the pathological mechanism of PCOS, and to find potential therapeutic methods that can alleviate the pathological mechanism of PCOS by targeting autophagy. Relevant literatures were searched in the following databases, including: PubMed, MEDLINE, Web of Science, Scopus. The search terms were "autophagy", "PCOS", "polycystic ovary syndrome", "ovulation", "hyperandrogenemia", "insulin resistance", "inflammatory state", "circadian rhythm" and "treatment", which were combined according to the retrieval methods of different databases. Through analysis, we uncovered that abnormal levels of autophagy were closely related to abnormal ovulation, insulin resistance, hyperandrogenemia, and low-grade inflammation in patients with PCOS. Lifestyle intervention, melatonin, vitamin D, and probiotics, etc. were able to improve the pathological mechanism of PCOS via targeting autophagy. In conclusion, autophagy disorder is a key pathological mechanism in PCOS and is also a potential target for drug development and design.
Keyphrases
- polycystic ovary syndrome
- insulin resistance
- cell death
- oxidative stress
- endoplasmic reticulum stress
- signaling pathway
- low grade
- metabolic syndrome
- adipose tissue
- skeletal muscle
- high fat diet
- type diabetes
- public health
- high grade
- physical activity
- machine learning
- blood pressure
- weight loss
- artificial intelligence
- big data
- risk assessment
- combination therapy
- smoking cessation