New Cutoffs for the Biochemical Diagnosis of Adrenal Insufficiency after ACTH Stimulation using Specific Cortisol Assays.

Bradley R Javorsky Hershel Raff Ty B CarrollAlicia Algeciras-SchimnichRavinder Jit SinghJessica M Colón-FrancoJames W Findling

Published in: Journal of the Endocrine Society (2021)

To reduce false positive ACTH stimulation testing, we recommend a new serum cortisol cutoff of 14 to 15 μg/dL depending on the assay used (instead of the historical value of 18 μg/dL with older polyclonal antibody assays). Clinicians should be aware of the new cutoffs for the assays available to them when evaluating patients for AI.

Keyphrases

high throughput
end stage renal disease
chronic kidney disease
palliative care
peritoneal dialysis
artificial intelligence
physical activity