Global white matter structural integrity mediates the effect of age on ischemic stroke outcomes.
Mark R EthertonMarkus D SchirmerMaria Clara Zanon ZotinPamela M RistGregoire BoulouisArne LauerOna WuNatalia S RostPublished in: International journal of stroke : official journal of the International Stroke Society (2021)
As a marker of global white matter microstructural injury, increased PSMD mediates the effect of increased age to contribute to poor acute ischemic stroke functional outcomes. PSMD could serve as a putative radiographic marker of brain age for stroke outcomes prognostication.