Gut Microbiota Dysbiosis Strengthens Kupffer Cell-mediated Hepatitis B Virus Persistence through Inducing Endotoxemia in Mice.

Wenqing ZhouJinzhuo LuoXiaohong XieShangqing YangDan ZhuHongming HuangDongliang YangJia Liu

Published in: Journal of clinical and translational hepatology (2021)

Our results suggest that dysbiosis of the gut microbiota in mice leads to endotoxemia, which induces KC IL-10 production and strengthens KC-mediated T cell suppression, and thus facilitates HBV persistence.

Keyphrases

hepatitis b virus
liver failure
high fat diet induced
lps induced
single cell
cell therapy
type diabetes
adipose tissue
metabolic syndrome
stem cells
mesenchymal stem cells