Anticipation of Relapse and Acute Graft-Versus-Host Disease after Allogeneic Peripheral Blood Stem Cell Transplantation: The Fundamental Role of Antigen-Presenting (Dendritic) Cells.
Khalid Ali NasifAwad S Al SamghanNahla El-SharkawyAmr M AbassEbtesam ElgezawySafaa A A KhaledMahmoud Ibrahim ElbadryMarwa M ThabetPublished in: Journal of inflammation research (2022)
This study analyzed DCs in PBSC grafts, using novel specific MoAbs and flow cytometry. Our data showed that higher donor DC1 counts were linked to the incidence of aGVHD and DC2 with relapse. We propose a fundamental role for DC-graft monitoring in anticipating aGVHD and disease relapse.
Keyphrases
- stem cell transplantation
- dendritic cells
- peripheral blood
- flow cytometry
- high dose
- free survival
- regulatory t cells
- immune response
- liver failure
- electronic health record
- respiratory failure
- case report
- machine learning
- aortic dissection
- hepatitis b virus
- acute respiratory distress syndrome
- data analysis
- deep learning
- hematopoietic stem cell
- mechanical ventilation