Mitochondrial defects and metabolic vulnerabilities in Lynch syndrome-associated MSH2-deficient endometrial cancer.
Mikayla Borthwick BowenBrenda MelendezQian ZhangDiana MorenoLeah PeraltaWai Kin ChanCollene JeterLin TanM Anna ZalPhilip L LorenziKenneth DunnerRichard K YangRussell R BroaddusJoseph CelestinoNisha GokulElizabeth WhitleyRosemarie SchmandtKaren LuHyun-Eui KimMelinda S YatesPublished in: bioRxiv : the preprint server for biology (2024)
This is the first study to report mitochondrial dysfunction contributing to MSH2-deficient endometrial cancer development, identifying a noncanonical pathway for MSH2 deficient carcinogenesis, which also imparts vulnerability to metabolic targeting.