Impacts of genotypic variants on survival following reoperation for recurrent glioblastoma.
Antonio DonoPing ZhuEmma HolmesTakeshi TakayasuJay-Jiguang ZhuAngel I BlancoSigmund HsuMeenakshi B BhattacharjeeLeomar Y BallesterDong H KimYoshua EsquenaziNitin TandonPublished in: Journal of neuro-oncology (2022)
Maximal safe re-resection significantly lengthens PPS regardless of genetic makeup, but reoperations are especially beneficial for IDH-WT rGBMs with EGFR and CDKN2A/B mutations with TP53-WT, and NF1-WT. Histopathology at recurrence may be an imperfect gauge of disease severity at progression and the imaging progression may be more reflective of the prognosis.
Keyphrases
- copy number
- small cell lung cancer
- free survival
- high resolution
- signaling pathway
- epidermal growth factor receptor
- tyrosine kinase
- heart rate
- lps induced
- low grade
- ultrasound guided
- oxidative stress
- gene expression
- blood pressure
- pi k akt
- immune response
- high grade
- photodynamic therapy
- inflammatory response
- mass spectrometry