Insight on Infections in Diabetic Setting.
Bianca PariMatteo GallucciAlberto GhigoMaria Felice BrizziPublished in: Biomedicines (2023)
The correlation between diabetes mellitus and infectious diseases is widely recognized. DM patients are characterized by the impaired function of the immune system. This translates into the occurrence of a variety of infections, including urinary tract, skin and surgical site infections, pneumonia, tuberculosis, and, more recently, SARS-CoV-2. Hyperglycemia has been identified as a relevant factor contributing to unfavorable outcomes in hospitalized patients including SARS-CoV-2 patients. Several studies have been performed proving that to maintain the proper and stringent monitoring of glycemia, a balanced diet and physical activity is mandatory to reduce the risk of infections and their associated complications. This review is focused on the mechanisms accounting for the increased susceptibility of DM patients to infections, with particular attention to the impact of newly introduced hypoglycemic drugs in sepsis management.
Keyphrases
- sars cov
- end stage renal disease
- physical activity
- newly diagnosed
- ejection fraction
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- risk assessment
- working memory
- intensive care unit
- insulin resistance
- depressive symptoms
- hepatitis c virus
- metabolic syndrome
- risk factors
- weight loss
- hiv infected
- wound healing
- mycobacterium tuberculosis
- pulmonary tuberculosis
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- soft tissue
- glycemic control