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Temporal ordering of omics and multiomic events inferred from time-series data.

Sandeep KaurTimothy J PetersPengyi YangLaurence Don Wai LuuJenny VuongJames R KrycerSeán I O'Donoghue
Published in: NPJ systems biology and applications (2020)
Temporal changes in omics events can now be routinely measured; however, current analysis methods are often inadequate, especially for multiomics experiments. We report a novel analysis method that can infer event ordering at better temporal resolution than the experiment, and integrates omic events into two concise visualizations (event maps and sparklines). Testing our method gave results well-correlated with prior knowledge and indicated it streamlines analysis of time-series data.
Keyphrases
  • electronic health record
  • healthcare
  • single cell
  • big data
  • machine learning
  • single molecule
  • deep learning