Prefrontal inhibition of neuronal Kv 7 channels enhances prepulse inhibition of acoustic startle reflex and resistance to hypofrontality.

Jing WangWenwen YuQin GaoChuanxia JuKe-Wei Wang

Published in: British journal of pharmacology (2020)

Both genetic and pharmacological inhibition of Kv 7 channels alleviated PPI and cognitive deficits. Mechanistically, inhibition of Kv 7 channels promotes synaptic transmission and activates Akt1/GSK-3β signalling.

Keyphrases

signaling pathway
cell proliferation
image quality
magnetic resonance imaging
magnetic resonance
transcranial magnetic stimulation
dna methylation
copy number
blood brain barrier
subarachnoid hemorrhage
high frequency
cerebral ischemia
protein protein