Computed tomography angiography versus Agatston score for diagnosis of coronary artery disease in patients with stable chest pain: individual patient data meta-analysis of the international COME-CCT Consortium.
Viktoria WieskeMario WaltherBenjamin DubourgHatem AlkadhiBjarne L NørgaardMatthijs F L MeijsAxel C P DiederichsenYung-Liang WanHans MickleyKonstantin NikolaouAbbas A ShabestariBjørn A HalvorsenEugenio MartuscelliKai SunBernhard A HerzogRoy P MarcusSebastian LeschkaMario J GarciaKristian A OvrehusJuhani KnuutiVladymir Mendoza-RodriguezNuno BettencourtSimone MuragliaRonny R BuechelPhilipp A KaufmannElke ZimmermannJean-Claude TardifMatthew J BudoffPeter SchlattmannMarc Deweynull nullPublished in: European radiology (2022)
• CTA showed significantly higher diagnostic accuracy (81.1%, 95% confidence interval [CI]: 77.5 to 84.1%) for diagnosis of coronary artery disease when compared to the Agatston score (68.8%, 95% CI: 64.2 to 73.1%, p < 0.001). • Diagnostic performance of CTA was not affected by increased amount of calcium and was not significantly different in patients with low to intermediate (1 to <100, 100-400) versus moderate to high Agatston scores (401-1000, > 1000). • Seventeen percent of patients with an Agatston score of zero showed obstructive coronary artery disease by invasive angiography showing absence of coronary artery calcium cannot reliably exclude coronary artery disease.
Keyphrases
- coronary artery disease
- coronary artery
- percutaneous coronary intervention
- cardiovascular events
- coronary artery bypass grafting
- pulmonary artery
- computed tomography
- optical coherence tomography
- case report
- type diabetes
- electronic health record
- heart failure
- cardiovascular disease
- left ventricular
- transcatheter aortic valve replacement
- atrial fibrillation
- image quality
- pulmonary arterial hypertension