Multianalyte Prognostic Signature Including Circulating Tumor DNA and Circulating Tumor Cells in Patients With Advanced Pancreatic Adenocarcinoma.
William J ChapinJacob E TillWei-Ting HwangJennifer R EadsThomas B KarasicPeter J O'DwyerCharles J SchneiderUrsina R TeitelbaumJanae RomeoTaylor A BlackTheresa E ChristensenColleen Redlinger TaberyAmanda K L AndersonMegan SladeMichael J LaRiviereStephanie S YeeKim A ReissMark H O'HaraErica L CarpenterPublished in: JCO precision oncology (2022)
A multianalyte prognostic signature containing CTCs, ctKRAS, and cfDNA concentration outperformed a model containing traditional clinical variables alone suggesting that CTCs, ctKRAS, and cfDNA provide prognostic information complementary to traditional clinical variables in advanced PDAC.