Missense mutations in Myc Box I influence nucleocytoplasmic transport to promote leukemogenesis.
Nancy B J ArthurKeegan A ChristensenKathleen ManninoMarianna B RuzinovaAshutosh KumarAgata GruszczynskaRyan B DayPetra Erdmann GilmoreYiling MiRobert W SprungConner R YorkRobert R TownsendDavid H SpencerStephen M SykesFrancesca FerraroPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
This study uncovers that MBI MYC mutations alter RNA nucleocytoplasmic transport mechanisms to contribute to the development of hematopoietic malignancies.