Microglial phagocytosis dysfunction in the dentate gyrus is related to local neuronal activity in a genetic model of epilepsy.
Virginia Sierra-TorreAinhoa Plaza-ZabalaPaolo BonifaziOihane AbiegaIrune Díaz-AparicioSaara TegelbergAnna-Elina LehesjokiJorge ValeroAmanda SierraPublished in: Epilepsia (2020)
These results suggest a complex crosstalk between apoptosis, phagocytosis, and neuronal activity, hinting that local neuronal activity could be related to phagocytosis dysfunction in Cstb KO mice. Overall, these data suggest that phagocytosis impairment is an early feature of hippocampal damage in epilepsy and opens novel therapeutic approaches for epileptic patients based on targeting microglial phagocytosis.
Keyphrases
- oxidative stress
- cerebral ischemia
- end stage renal disease
- inflammatory response
- newly diagnosed
- ejection fraction
- machine learning
- chronic kidney disease
- lipopolysaccharide induced
- lps induced
- prognostic factors
- adipose tissue
- endoplasmic reticulum stress
- deep learning
- cancer therapy
- big data
- metabolic syndrome
- gene expression
- patient reported outcomes
- insulin resistance
- signaling pathway
- cell proliferation
- high fat diet induced