Whole genome analysis of plasma fibrinogen reveals population-differentiated genetic regulators with putative liver roles.
Jennifer E HuffmanJayna NicolasJulie HahnAdam S HeathLaura M RaffieldLisa R YanekJennifer A BrodyFlorian ThibordLaura AlmasyTraci M BartzLawrence F BielakRussell P BowlerGermán D CarrasquillaDaniel I ChasmanMing-Huei ChenDavid B EmmertMohsen GhanbariJeffery HaessleJouke-Jan HottengaMarcus E KleberNgoc-Quynh LeJiwon LeeJoshua P LewisRuifang Li-GaoJian'an LuanAnni MalmbergMassimo ManginoRiccardo E MarioniAngel Martinez-PerezNathan PankratzOzren PolasekAnne RichmondBenjamin At RodriguezJerome I RotterMaristella SteriPierre SuchonStella TrompetStefan WeissMarjan ZarePaul AuerMichael H ChoParaskevi ChristofidouGail DaviesEco de GeusJean-François DeleuzeGraciela E DelgadoLynette EkunweNauder FaradayMartin GögeleAndreas GreinacherGao HeTom HowardPeter K JoshiTuomas O KilpeläinenJari LahtiAllan LinnebergSilvia NaitzaRaymond NoordamFerran Paüls-VergésStephen S RichFrits R RosendaalDavies AdeloyeKathleen A RyanJuan Carlos SoutoFrank Ja van RooijHeming WangWei ZhaoLewis C BeckerAndrew BeswickMichael R BrownBrian E CadeHarry CampbellKelly ChoJames D CrapoJoanne E CurranMoniek Pm de MaatMargaret DoylePaul ElliottJames S FloydChristian FuchsbergerNiels GrarupXiuqing GuoSarah E HarrisLifang HouIvana KolcicCharles KooperbergCristina MenniMatthias NauckJeffrey R O'ConnellValeria OrrùBruce M PsatyKatri RäikkönenJennifer A SmithJose Manuel SoriaDavid J StottAstrid van Hylckama VliegHugh WatkinsGonneke WillemsenPeter WilsonYoav Ben-ShlomoJohn E BlangeroDorret BoomsmaSimon R CoxAbbas DehghanJohan G ErikssonEdoardo FiorilloMyriam FornageTorben HansenCaroline HaywardM Arfan IkramJ Wouter JukemaSharon Lr KardiaLeslie A LangeWinfried MärzRasika A MathiasBraxton D MitchellDennis O Mook-KanamoriPierre-Emmanuel MorangeOluf PedersenPeter P PramstallerSusan RedlineAlexander ReinerPaul M RidkerEdwin K SilvermanTim D SpectorUwe VölkerNick WarehamJames F WilsonJie Yaonull nullnull nullDavid-Alexandre TrégouëtAndrew D JohnsonAlisa S WolbergPaul S de VriesMaria Sabater-LlealAlanna C MorrisonNicholas L SmithPublished in: medRxiv : the preprint server for health sciences (2023)
Largest and most diverse genetic study of plasma fibrinogen identifies 54 regions (18 novel), housing 69 conditionally distinct variants (20 novel).Sufficient power achieved to identify signal driven by African population variant.Links to (1) liver enzyme, blood cell and lipid genetic signals, (2) liver regulatory elements, and (3) thrombotic and inflammatory disease.