TGF-β3 increases the severity of radiation-induced oral mucositis and salivary gland fibrosis in a mouse model.

Ingunn HansonInga Solgård JuvkamOlga ZlygostevaTine Merete SølandHilde Kanli GaltungEirik MalinenNina Frederike Jeppesen Edin

Published in: International journal of radiation biology (2024)

When repeatedly administered during fractionated RT at the current dose, TGF-β3 treatment increased acute H&N radiation toxicities and increased mortality. Furthermore, TGF-β3 treatment may increase the severity of radiation-induced salivary gland fibrosis.

Keyphrases

radiation induced
radiation therapy
mouse model
transforming growth factor
liver failure
cardiovascular events
risk factors
type diabetes
signaling pathway
coronary artery disease
combination therapy
hepatitis b virus
liver fibrosis