Nrf2 mediates the effects of shionone on silica-induced pulmonary fibrosis.

Guiyun WangWeixi XieLang DengXiaoting HuangMei SunWei LiuSiyuan Tang

Published in: Chinese medicine (2024)

SHI plays a significant role in stimulating the Nrf2 pathway, thereby defending against silica-induced oxidative stress and inflammatory reactions in macrophages, and inhibiting the conversion of fibroblasts to myofibroblasts due to TGF-β. This suggests that SHI is a viable option for treating lung inflammation and fibrosis in mice suffering from silicosis.

Keyphrases

pulmonary fibrosis
oxidative stress
diabetic rats
high glucose
signaling pathway
transforming growth factor
hydrogen peroxide
high fat diet induced
drug induced
nitric oxide
wild type
stress induced