Ursodeoxycholic acid prevents ventricular conduction slowing and arrhythmia by restoring T-type calcium current in fetuses during cholestasis.
Oladipupo AdeyemiAnita Alvarez-LaviadaFrancisca SchultzEffendi IbrahimMichael TraunerCatherine WilliamsonAlexey V GlukhovJulia GorelikPublished in: PloS one (2017)
Our findings demonstrate that ICa,T plays a significant role in ICP-associated fetal cardiac conduction slowing and arrhythmogenesis, and is an important component of the fetus-specific anti-arrhythmic activity of UDCA.