GLP-1 Analogue, Exendin-4, Modulates MAPKs Activity but not the Heat Shock Response in Human HepG2 Cells.

Dhanya MadhuMaha HammadSina KavalakattAbdelkrim KhadirAli Tiss

Published in: Proteomics. Clinical applications (2017)

Identifying new pathways modulated by GLP-1 analogues will provide further insights into their benefits beyond their currently recognized roles in glycemic control, such as MAPK activity, energy homeostasis, and body weight decrease.

Keyphrases

body weight
glycemic control
heat shock
type diabetes
endothelial cells
heat stress
signaling pathway
oxidative stress
blood glucose
heat shock protein
weight loss
molecular docking
pi k akt
insulin resistance
adipose tissue