Nerve-tumour interaction enhances the aggressiveness of oral squamous cell carcinoma.

Tsung-Lun LeePo-Hsien ChiuWing-Yin LiMuh-Hwa YangPei-Yin WeiPen-Yuan ChuYi-Fen WangShyh-Kuan Tai

Published in: Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery (2019)

These results clearly indicated the presence of nerve-tumour interaction that involved paracrine influences leading to aggressiveness of OSCC. Further investigations are required to explore key cell types and molecules involved in nerve-tumour interactions for future therapeutic targeting of PNI in OSCC.

Keyphrases

peripheral nerve
cell therapy
stem cells
cancer therapy