Association of peripheral basophils with tumor M2 macrophage infiltration and outcomes of the anti-PD-1 inhibitor plus chemotherapy combination in advanced gastric cancer.

Dongbing ZhaoYaopeng QiuRenyi ZhangXiaoqing LiHuayuan LiangMinghao WangFengping LiMansheng ZhuGengtai YeHao LiuGuoxin LiLiying Zhao

Published in: Journal of translational medicine (2022)

The peripheral basophil count was observed to be a potential biomarker of anti-PD-1 efficacy for advanced gastric cancer. Moreover, basophils may induce an immune-evasive tumor microenvironment by increasing M2 macrophage infiltration, which could be a potential immunotherapeutic target for advanced gastric cancer.

Keyphrases

neoadjuvant chemotherapy
chemotherapy induced
locally advanced
adipose tissue
squamous cell carcinoma
rectal cancer
peripheral blood
radiation therapy
type diabetes
human health
metabolic syndrome
risk assessment
skeletal muscle
climate change