Imaging of Cancer γ-Secretase Activity Using an Inhibitor-Based PET Probe.
Pengju NieTeja KalidindiVeronica L NagleXianzhong WuThomas LiGeorge P LiaoGeorgia FrostKelly E HenryBlesida PunzalanLukas Michael CarterJason S LewisNaga Vara Kishore PillarsettyYue-Ming LiPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)
[124I]-PN67 is a novel PET imaging agent that enables assessment of γ-secretase activity and target engagement of clinical GSIs.