SEMA6A/RhoA/YAP axis mediates tumor-stroma interactions and prevents response to dual BRAF/MEK inhibition in BRAF-mutant melanoma.
Rossella LoriaValentina LaquintanaStefano ScaleraRocco FraioliValentina CapraraItalia FalconeChiara BazzichettoMarta Di MartileLaura RosanòDonatella Del BufaloGianluca BossiIsabella SperdutiIrene TerrenatoPaolo ViscaSilvia SodduMichele MilellaGennaro CilibertoRita FalcioniVirginia FerraresiGiulia BonPublished in: Journal of experimental & clinical cancer research : CR (2022)
Overall, our results indicate that SEMA6A contributes to microenvironment-coordinated evasion of melanoma cells from dual BRAF/MEK inhibition and it might be a good candidate predictor of short-term benefit from dual BRAF/MEK inhibition.