Enhanced BDNF and TrkB Activation Enhance GABA Neurotransmission in Cerebellum in Hyperammonemia.

Yaiza M ArenasMar Martínez-GarcíaMarta Llansola Vicente Felipo

Published in: International journal of molecular sciences (2022)

receptors in the membrane and chloride gradient. These factors enhance GABAergic neurotransmission in the cerebellum. Blocking TrkB or the TNFR1-SP1PR2-CCL2-CCR2-BDNF-TrkB pathway would improve motor function in patients with hepatic encephalopathy and likely with other pathologies associated with neuroinflammation.

Keyphrases

stress induced
traumatic brain injury
early onset
dendritic cells
cognitive impairment
liver fibrosis
lps induced
blood brain barrier