Characterizing the Genetic Architecture of Parkinson's Disease in Latinos.
Douglas P LoeschAndrea R V R HorimotoKarl HeilbronElif I SarihanMiguel Inca-MartinezEmily MasonMario Cornejo-OlivasLuis TorresPilar MazzettiCarlos CosentinoElison Sarapura-CastroAndrea Rivera-ValdiviaAngel C MedinaElena DieguezVictor RaggioAndres LescanoVitor TumasVanderci BorgesHenrique B FerrazCarlos R RiederArtur Schumacher-SchuhBruno L Santos-LobatoCarlos Velez-PardoMarlene Jimenez-Del-RioFrancisco LoperaSonia MorenoPedro Chana-CuevasWilliam FernandezGonzalo ArboledaHumberto ArboledaCarlos E Arboleda-BustosDora YearoutCyrus P Zabetiannull nullPaul CannonTimothy A ThorntonTimothy D O'ConnorIgnacio Fernandez Matanull nullPublished in: Annals of neurology (2021)
This study demonstrated the importance of the SNCA locus for the etiology of PD in Latinos. By leveraging the demographic history of our cohort via admixture mapping, we identified two potential PD risk loci that merit further study. ANN NEUROL 2021;90:353-365.