Folic acid supplementation improved cognitive deficits associated with lithium administration during pregnancy in rat offspring.
Samaneh KakhkiMehrnoush GoodarziAli Abbaszade-CheraghealiMojgan RajabiAmir Hossein MasoumipourSeyed Reza KhatibiFarimah BeheshtiPublished in: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (2023)
According to the results, prenatal exposure to a high dose of lithium (30 mg/kg) leads to foetal neurodevelopmental disorder and growth restriction through various mechanisms more likely attributed to hypothyroidism, which means it should be either prohibited or prescribed cautiously during pregnancy.