Folic acid supplementation improved cognitive deficits associated with lithium administration during pregnancy in rat offspring.

Samaneh KakhkiMehrnoush GoodarziAli Abbaszade-CheraghealiMojgan RajabiAmir Hossein MasoumipourSeyed Reza KhatibiFarimah Beheshti

Published in: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (2023)

According to the results, prenatal exposure to a high dose of lithium (30 mg/kg) leads to foetal neurodevelopmental disorder and growth restriction through various mechanisms more likely attributed to hypothyroidism, which means it should be either prohibited or prescribed cautiously during pregnancy.

Keyphrases

high dose
solid state
low dose
pregnant women
stem cell transplantation
high fat diet
oxidative stress
type diabetes
adipose tissue
insulin resistance