Use and misuse of biomarkers and the role of D-dimer and C-reactive protein in the management of COVID-19: A post-hoc analysis of a prospective cohort study.
Fabio Augusto Rodrigues GonçalvesBruno Adler Maccagnan Pinheiro BesenClarice Antunes de LimaAline Pivetta CoráAntônio José Rodrigues PereiraSandro Felix PerazzioChristiane Pereira GouveaLuiz Augusto Marcondes FonsecaEvelinda Marramon TrindadeNairo Massakazu SumitaAlberto Jose da Silva DuarteArnaldo Lichtensteinnull nullEloisa BonfaEdivaldo M UtiyamaAluisio C SeguradoBeatriz PerondiAnna Miethke-MoraisAmanda C MontalLeila HarimaSolange R G FuscoMarjorie F SilvaMarcelo C RochaIzabel MarcilioIzabel Cristina RiosFabiane Yumi Ogihara KawanoMaria Amélia de JesusÉsper George KallasCarolina CarmoClarice TanakaHeraldo Possolo de SouzaJulio F M MarchiniCarlos CarvalhoJuliana C FerreiraAnna Sara Shafferman LevinMaura Salaroli OliveiraThaís GuimarãesCarolina Dos Santos LázariEster SabinoMarcello M C MagriTarcisio E P Barros-FilhoMaria Cristina Peres Braido FranciscoSilvia F CostaPublished in: Clinics (Sao Paulo, Brazil) (2021)
D-dimer and CRP levels were associated with higher hospital mortality and a higher incidence of VTE. D-dimer was more strongly associated with VTE, although its discriminative ability was poor, while CRP was a stronger predictor of hospital mortality. Their use outside the usual indications should not be modified and should be discouraged.