Excitoprotective effects of conditional tau reduction in excitatory neurons and in adulthood.
Yuliya VoskobiynykZhiyong LiJ Nicholas CochranM Natalie DavisNancy V N CarulloRose B CreedSusan C BuckinghamAlicia M HallScott M WilsonErik D RobersonPublished in: bioRxiv : the preprint server for biology (2024)
A new conditional tau knockout model was generated to study the protective effects of tau reduction against hyperexcitability. Conditional tau reduction in excitatory, but not inhibitory, neurons was excitoprotective, and induced tau reduction in adulthood was excitoprotective without adverse effects.