Lycopene Prevents Phthalate-Induced Cognitive Impairment via Modulating Ferroptosis.
Hao-Ran WangMu-Zi LiJia-Gen CuiHao ZhangYi ZhaoJin-Long LiPublished in: Journal of agricultural and food chemistry (2023)
Di-(2-ethylhexyl) phthalate (DEHP) is frequently used as a plasticizer in industrial and agricultural products. DEHP can cause severe neurotoxicity, such as impaired learning and memory function. Lycopene (LYC) as a carotenoid exerts excellent antioxidant capacity and therapeutic effects in neurodegenerative diseases. However, whether LYC can prevent the cognitive impairment induced by DEHP and the specific mechanisms are unclear. In the present study, the behavioral test results suggested that LYC alleviated the learning and memory impairment induced by DEHP. The histopathological data revealed that LYC attenuated DEHP-induced disordered arrangement of the neurons in the CA1 and CA3 regions of the hippocampus tissue. Moreover, LYC inhibited the occurrence of DEHP-induced ferroptosis via regulating iron metabolism, inhibiting lipid peroxidation, and activating the cysteine transporter and nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (NrF2/HO-1) signaling pathway. Overall, the study contributes novel perspectives into the potential mechanisms of LYC preventing phthalate-induced cognitive impairment in the hippocampus.
Keyphrases
- cognitive impairment
- signaling pathway
- high glucose
- diabetic rats
- nuclear factor
- drug induced
- cell death
- risk assessment
- heavy metals
- toll like receptor
- pi k akt
- epithelial mesenchymal transition
- endothelial cells
- spinal cord
- escherichia coli
- single cell
- immune response
- early onset
- electronic health record
- cystic fibrosis
- induced apoptosis
- subarachnoid hemorrhage
- living cells
- single molecule