Small molecule-facilitated anion transporters in cells for a novel therapeutic approach to cystic fibrosis.
Michele FioreClaudia CossuValeria CapurroCristiana PiccoAlessandra LudovicoMarcin MielczarekIsrael Carreira-BarralEmanuela CaciDebora BaroniRoberto QuesadaOscar MoranPublished in: British journal of pharmacology (2019)
These anionophores, at low concentrations, transported chloride and bicarbonate across cell membranes, without affecting CFTR function. They therefore provide promising starting points for the development of novel treatments for CF.