Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4.
Jitske van den BulkEls M E VerdegaalDina RuanoMarieke E IjsselsteijnMarten VisserRuud van der BreggenThomas DuhenManon van der PloegNatasja L de VriesJan OostingKoen C M J PeetersAndrew D WeinbergArantza Farina-SarasquetaSjoerd H van der BurgNoel F C C de MirandaPublished in: Genome medicine (2019)
We have detected neoantigen-targeted reactivity by autologous T cells in mismatch repair-proficient colorectal cancers of the CMS4 subtype. These findings warrant the development of specific immunotherapeutic strategies that selectively boost the activity of neoantigen-specific T cells and target the TGF-β pathway to reinforce T cell reactivity in this patient group.