FGFR mRNA Expression in Cholangiocarcinoma and its Correlation with FGFR2 Fusion Status and Immune Signatures.

Vishwajith Sridharan Vikram Deshpande Abhijit Chougule Islam Baiev Stephanie Reyes Emily G Barr Fritcher Jochen K Lennerz William R Sukov Benjamin R Kipp David Tsai Ting Vikram Deshpande Lipika Goyal

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

FGFR mRNA overexpression occurs frequently in cholangiocarcinoma in the absence of genetic FGFR alterations. This study identifies a molecular subpopulation in cholangiocarcinoma for which further investigation of FGFR inhibitors is merited outside currently approved indications.

Keyphrases

genome wide
cell proliferation
gene expression
copy number
drug administration