Effect of low-dose factor VIII prophylaxis therapy on bone mineral density and 25(OH) vitamin D level in children with severe haemophilia A.

Nevine Gamal AndrawesManal Hashem FayekNouran Yousef Salah El-DinRaguia Atef Mostafa

Published in: Haemophilia : the official journal of the World Federation of Hemophilia (2019)

Severe haemophilia A patients showed significantly lower 25(OH) vit-D3 and DEXA than controls. Hence, vitamin D deficiency should be tested in all people with haemophilia for early diagnosis and treatment. Low-dose prophylaxis in severe haemophilia preserves BMD and increases vitamin D. Further studies are required to evaluate the effect of different prophylaxis protocols on BMD and haemophilic arthropathy.

Keyphrases

low dose
bone mineral density
postmenopausal women
end stage renal disease
early onset
high dose
body composition
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
young adults
stem cells
drug induced
smoking cessation